Matrix Biology Highlights.

1). Context dependent protective or promotive laminin function Reference|Spenlé, C., Lefebvre, O., Lacroute, J., Méchine-Neuville, A., Barreau, F., Blottière, H.M., Duclos, B., Arnold, C., Hussenet. T., Hemmerlé, J., Gullberg, D., Kedinger, M., Sorokin, L., Orend, G., Simon-Assmann, P. “The laminin response in inflammatory bowel disease: protection or malignancy?” 2014. PLoS One 9(10):e111336. http://www.ncbi.nlm.nih.gov/pubmed/25347196 A recent report from Spenlé and colleagues published in PLoSOne describes abnormal overexpression of lamininα1 andα5 in human andmouse colitis samples that was associated with p53 expression. To further explore the relevance of these observations, the authors utilized transgenic mice that overexpress intestine-specific Lama1 or Lama5. Thesemicewere less vulnerable to inflammation butmore prone to cancer progression in vivo (Fig. 1). These results define unique laminin function related to gastrointestinal inflammation and cancer. 2). Jun and the diffuse large B-cell lymphoma (DLBCL) microenvironment Reference|Blonska,M., Zhu, Y., Chuang, H.H., You,M.J., Kunkalla, K., Vega, F., Lin, X. “Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment.” 2014. Blood http://www.ncbi.nlm.nih.gov/pubmed/25533033.